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In addition, it attenuates the nuclear translocation of NFATc1, a crucial downstream effector of the RANKL signaling pathway that is indispensable for the terminal stage of osteoclast differentiation (Mabilleau et al., 2016)
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Combination therapy has also resulted in improved glucoregulation via an increase in insulin sensitivity, an observation that has been linked to the recovery of pancreatic β-cell function 21
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